Patents & Publications
- Tetrahedron’s proprietary patents
- New selenohydroxy acids and their derivatives, applications in nutrition, cosmetics and pharmaceutics (WO2006008190)
- Process for preparing 2-hydroxy-4-methylselenobutyric acid, alone or as a mixture with its sulphur-containing analogue, and uses thereof in nutrition, in particular in animal nutrition (WO2008049927)
- Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds, and applications thereof in the fields of nutrition, cosmetics, and pharmaceuticals (WO2010023291)
- Method for the synthesis of 2-thiohistidine and the like (WO2011042478)
- Method for the synthesis of ergothioneine and the like (WO2011042480)
- Organoselenium compounds, methods for producing same, and pharmaceutical uses thereof in particular as antitumor agents (WO2015155453)
- Novel 5-acylsulfanyl-histidine compounds as precursors of the corresponding 5-sulfanyl-histidines and their disulphides (WO 2015181507)
- Method for producing pure L-hercynine (WO2016042273)
- Tetrahedron’s license
- Use of L-2-Thiohistidine or one of its derivatives as a depigmenting agent in cosmetics (US2008161377)
- Tetrahedron’s publications
- Simultaneous speciation of selenomethionine and 2-hydroxy-4-methylselenobutanoic acid by HPLC–ICP MS in biological samples -VACCHINA V., MOUTET M., YADAN JC., DE BAENEC F., KUDLA B., LOBINSKI R. – 2010 – J. of Chrom. B, 878:1178-1180
- Cysteine as a sustainable sulfur reagent for the protecting-group-free synthesis of sulfur-containing amino acids: biomimetic synthesis ofL-ergothioneine in water – ERDELMEIER I., DAUNAY S., LEBEL R., FARESCOUR L., YADAN JC. – 2012 – Green Chem., 14:2256-2265
- Intake assessment of L-ergothioneine in some European countries and in the United States – RAMIREZ-MARTINEZ A., WESOLEK N., YADAN JC., MOUTET M., ROUDOT AC. – 2015 – Human and Ecological Risk Assessment, 22(3):667-677
- Reproductive safety evaluation of L-ergothioneine – FORSTER R., SPEZIA F., PAPINEAU D., SABADIE C.,ERDELMEIER I., MOUTET M., YADAN JC. – 2015 – Food Chem. Toxicol., 80:85-91
- Short protecting-group-free synthesis of 5-acetylsulfanyl-histidines in water: novel precursors of 5-sulfanyl-histidine and itsanalogues – DAUNAY S., LEBEL R.,FARESCOUR L., YADAN JC., ERDELMEIER I. – 2016 – Org. Biomol. Chem., 14:10473-10480
- Publications
From 1909 to 2000
- New base obtained from ergot of rye. Ergothioneine – TANRET C. – 1909 – C. R. Acad. Sci., 149:222-224
- Biosynthesis of ergothioneine and hercynine by mycobacteria – GENGHOF D.S., and VAN DAMME O. – 1964 – J. Bacteriol., 87(4):852-862
- Ergothioneine in microorganisms – MELVILLE D.B., GENGHOF D.S., INAMINE E., and KOVALENKO V. – 1956 – J. Biol. Chem., 223(1):9-17
- Ergothioneine – MELVILLE D.B. – 1959 – Vitam. Horm., 17:155-204
- Biosynthesis of ergothioneine and hercynine by fungi and Actinomycetales – GENGHOF D.S. – 1970 – J. Bacteriol., 103(2):475-478
- The enzymatic α-N-methylation of histidine – ISHIKAWA Y., and MELVILLE D.B. – 1970 – J. Biol. Chem., 245(22):5967-5973
- Participation of an intermediate sulfoxide in the enzymatic thiolation of the imidazole ring of hercynine to form ergothioneine – ISHIKAWA Y., ISRAEL S.E., and MELVILLE D.B. – 1974 – J. Biol. Chem., 249(14):4420-4427
- [Incidence of herzynine, ergothioneine, homarine, trigonelline, glycocoll betaine, choline, trimethylamine, adenine and almost all amino acids of proteins in Limulus polyphemus L] – ACKERMANN D., and LIST P.H. – 1958 – Hoppe Seylers Z. Physiol. Chem., 313:30-36
- The uptake of ergothioneine from the soil into the latex of Hevea brasiliensis – AUDLEY B.G., and TAN C.H. – 1968 – Phytochemistry, 7(11):1999-2000
- On the origin of animal ergothioneine – MELVILLE D.B., OTKEN C.C., and KOVALENKO V. – 1955 – J. Biol. Chem., 216:325-331
- Blood ergothioneine in the germ-free chicken – MELVILLE D.B., and HORNER W.H. – 1953 – J. Biol. Chem., 202(1):187-191
- Studies on ergothioneine. II. Origin of ergothioneine in the animal organs – KONISHI T., TAMAKI N., TUNEMORI F., MASUMITU N., OKUMURA H., and HAMA T. – 1972 – Vitamins, 46(3):127-130
- The occurrence of ergothioneine in plant material – MELVILLE D.B., and EICH S. – 1956 – J. Biol. Chem., 218:647-651
- Ergothioneine and hercynine in Hevea brasiliensis latex – TAN C.H., and AUDLEY B.G. – 1968 – Phytochemistry, 7(1):109-118
- On ergothioneine in blood and diazo-reacting substances in maize – HUNTER G. – 1951 – Biochem. J., 48(3):265-270
- Studies on the metabolism of semen. VIII. Ergothioneine as a normal constituent of boar seminal plasma. Purification and crystallization. Site of formation and function – MANN T., and LEONE E. – 1953 – Biochem. J., 53(1):140-148
- A method for the determination of ergothioneine in blood – MELVILLE D.B., and LUBSCHEZ R. – 1953 – J. Biol. Chem., 200(1):275-285
- Tissue ergothioneine – MELVILLE D.B., HORNER W.H., and LUBSCHEZ R. – 1954 – J. Biol. Chem., 206(1):221-228
- Further studies on seminal ergothioneine of the pig – HEATH H., RIMINGTON C., and MANN T. – 1957 – Biochem. J., 65(2):369-373
- Semen composition and metabolism in the stallion and jackass – MANN T., MINOTAKIS C.S., and POLGE C. – 1963 – J. Reprod. Fertil., 5:109-122
- Ergothioneine in the central nervous system – BRIGGS I. – 1972 – J. Neurochem., 19(27):27-35
- Studies on ergothioneine. I. Distribution in the body and the subcellular fractions of liver – HAMA T., KONISHI T., TAMAKI N., TUNEMORI F., and OKUMURA H. – 1972 – Vitamins, 46(3):121-126
- Characteristics of the successive jets of ejaculated semen of stallions – KOSINIAK K. – 1975 – J. Reprod. Fertil. Suppl., 23:59-61
- Biochemistry of stallion semen – MANN T. – 1975 – J. Reprod. Ferti. Suppl., 23:47-52
- Studies on ergothioneine. V. Determination by High Performance Liquid Chromatography and application to metabolic research – MAYUMI T., KAWANO H., SAKAMOTO Y., SUEHISA E., KAWAI Y., and HAMA T. – 1978 – Chem. Pharm. Bull., 26(12):3772-3778
- Biochemical components of stallion seminal plasma before and after the breeding season – KOSINIAK K., and BITTMAR A. – 1981 – Anim. Reprod. Sci., 4(1):39-47
- Comparison of the 1H and 31P NMR spectra of erythrocytes and plasma from some Australian native animals: Bandicoot, Echidna, Koala, Little Penguin, Tammar Wallaby, Tasmanian Devil, Tree Kangaroo and Wombat – RAE C., SWEENEY K.J.E., KROCKENBERGER A.K., AGAR N.S., GALLAGHER C.H., and KUCHEL P.W. – 1993 – Comp. Haematol. Int., 3(2):71-80
- Influence of age and season on certain biochemical constituents of seminal plasma of Arabian horses – ABOU-AHMED M.M., EL-BELELY M.S., ISMAIL S.T., EL-BAGHDADY Y.R.M., and HEMEIDA N.A. – 1993 – Anim. Reprod. Sci., 32(3-4):237-244
- Ergothioneine distribution in bovine and porcine ocular tissues – SHIRES T.K., BRUMMEL M.C., PULIDO J.S., and STEGINK L.D. – 1997 – Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol., 117(1):117-120
- A note on antioxidant capacity of boar seminal plasma – STRZEZEK J., LAPKIEWICZ S., and LECEWICZ M. – 1999 – Anim. Sci. Pap. Rep., 17(4):181-188
- Relationship between nonprotein sulfhydryl concentration of seminal fluid and motility of spermatozoa in man – HAAG F.M., and MacLEOD J. – 1959 – J. Appl. Physiol., 14(1):27-30
- Ergothioneine content in normal and senile human cataractous lenses – SHUKLA Y., KULSHRESTHA O.P., and KHUTETA K.P. – 1981 – Indian J. Med. Res., 73:472-473
- Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1 – TAMAI I., YABUUCHI H., NEZU J., SAI Y., OKU A., SHIMANE M., and TSUJI A. – 1997 – FEBS Lett., 419(1):107-111
- Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations – YABUUCHI H., TAMAI I., NEZU J., SAKAMOTO K., OKU A., SHIMANE M., SAI Y., and TSUJI A. – 1999 – J. Pharmacol. Exp. Therap., 289(2):768-773
- Some effects of administering ergothioneine to rats – HEATH H., RIMINGTON C., SEARLE C. E., and LAWSON A. – 1952 – Biochem. J., 50(4):530-533
- The effect of age, sex and androgen on blood ergothioneine – MacKENZIE J.B., and MacKENZIE C.G. – 1957 – J. Biol. Chem., 225(2):651-658
- Studies on ergothioneine. VI. Distribution and fluctuations of ergothioneine in rats – KAWANO H., OTANI M., TAKEYAMA K., KAWAI Y., MAYUMI T., and HAMA T. – 1982 – Chem. Pharm. Bull., 30(5):1760-1765
- Transfer of ergothioneine to newborn and weanling rats – ONTKO J.A., and PHILLIPS P.H. – 1957 – Fed. Proceedings, 16(1):229
- The antioxidant action of ergothioneine – AKANMU D., CECCHINI R., ARUOMA O.I., and HALLIWELL B. – 1991 – Arch. Biochem. Biophys., 288(1):10-16
- Antioxidant action of ergothioneine: Assessment of its ability to scavenge peroxynitrite – ARUOMA O.I., WHITEMAN M., ENGLAND T.G., and HALLIWELL B. – 1997 – Biochem. Biophys. Res. Comm., 231(2):389-391
- The reduction of ferryl myoglobin by ergothioneine: a novel function for ergothioneine – ARDUINI A., EDDY L., and HOCHSTEIN P. – 1990 – Arch. Biochem. Biophys., 281(1):41-43
- Deactivation of singlet molecular oxygen by thiols and related compounds, possible protectors against skin photosensitivity – ROUGEE M., BENSASSON R.V., LAND E.J., and PARIENTE R. – 1988 – Photochem. Photobiol., 47(4):485-489
- Quenching of singlet molecular oxygen by carnosine and related antioxidants. Monitoring 1270-nm phosphorescence in aqueous media – EGOROV S.Y., KURELLA E.G., BOLDYREV A.A., and KRASNOVSKY A.A. Jr – 1997 – Biochem. Mol. Biol. Int., 41(4):687-694
- Some prevalent biomolecules as defenses against singlet oxygen damage – DAHL T.A., MIDDEN W.R., and HARTMAN P.E. – 1988 – Photochem. Photobiol., 47(3):357-362
- Interaction of ergothioneine with metal ions and metalloenzymes – HANLON D.P. – 1971 – J. Med. Chem., 14(11):1084-1087
- Metal complexes of ergothioneine – MOTOHASHI N., MORI I., SUGIURA Y., and TANAKA H. – 1974 – Chem. Pharm. Bull., 22(3):654-657
- Complexing of copper ion by ergothioneine – MOTOHASHI N., MORI I., and SUGIURA Y. – 1976 – Chem. Pharm. Bull., 24(10):2364-2368
- 2-Imidazolethiones protect ascorbic acid from oxidation induced by copper – SMITH R.C., and GORE J.Z. – 1990 – Biochim. Biophys. Acta, 1034(3):263-267
- Ergothioneine, histidine, and two naturally occurring histidine dipeptides as radioprotectors against gamma-irradiation inactivation of bacteriophages T4 and P22 – HARTMAN P.E., HARTMAN Z., and CITARDI M.J. – 1988 – Radiat. Res., 114(2):319-330
- Protection against oxidative damage and cell death by the natural antioxidant ergothioneine – ARUOMA O.I., SPENCER J.P., and MAHMOOD N. – 1999 – Food Chem. Toxicol., 37(11):1043-1053
- In vitro administration of ergothioneine failed to protect isolated ischaemic and reperfused rabbit heart – CARGNONI A., BERNOCCHI P., CECONI C., CURELLO S., and FERRARI R. – 1995 – Biochim. Biophys. Acta, 1270(2-3):173-178
- Studies on ergothioneine. IV. Effect of ergothioneine upon spermatozoa from guinea pigs – HAMA T., OKUMURA H., TAMAKI N., and KONISHI T. – 1973 – Yakugaku Zasshi, 93(3):369-373
- Studies on ergothioneine. IX. Ergothioneine stimulates mouse spermatozoa and fertilization in vitro – MAYUMI T., KAWANO H., KAWAI Y., and HAMA T. – 1984 – Dev. Growth Differ., 26(6):563-569
- Ergothioneine depletion in rabbit erythrocytes and its effect on methemoglobin formation and reversion – SPICER S.S., WOOLEY J.G., and KESSLER V. – 1951 – Proc. Soc. Exp. Biol. Med., 77(3):418-420
- The effect of diet on methemoglobin levels of nitrite-injected rats – MORTENSEN R.A. – 1953 – Arch. Biochem. Biophys., 46(1):241-243
- Studies on Ergothioneine. VIII. Preventive effects of ergothioneine on cadmium-induced teratogenesis – MAYUMI T., OKAMOTO K., YOSHIDA K., KAWAI Y., KAWANO H., HAMA T., and TANAKA K. – 1982 – Chem. Pharm. Bull., 30(6):2141-2146
- Studies on ergothioneine. X. Effects of ergothioneine on the hepatic drug metabolizing enzyme system and on experimental hepatic injury in rats – KAWANO H., CHO K., HARUNA Y., KAWAI Y., MAYUMI T., and HAMA T. – 1983 – Chem. Pharm. Bull., 31(5):1676-1681
- Unbound amino acid concentrations in plasma, erythrocytes, leukocytes and urine of patients with leukemia – McMENAMY R.H., LUND C.C., and WALLACH D.F.H. – 1960 – J. Clin. Invest., 39(11): 1688-1705
- Clinical analysis in intact erythrocytes using 1H spin echo NMR – REGLINSKI J., SMITH W.E., WILSON R., BUCHANAN L.M., McKILLOP J.H., THOMSON J.A., BRZESKI M., MARABANI M., and STURROCK R.D. – 1991 – Clin. Chim. Acta, 201(1-2):45-57
- 13C-Nuclear magnetic resonance and Raman spectroscopic studies on ionization and mercury complex of ergothioneine – MOTOHASHI N., MORI I., and SUGIURA Y. – 1976 – Chem. Pharm. Bull., 24(8):1737-1741
From 2001-2010
- Influence of selected cultural factors and postharvest storage on ergothioneine content of common button mushroom – DUBOST N.J., BEELMAN R.B., and ROYSE D.J. – 2007 – Int. J. of Med. Mushrooms, 9:163-176
- Supplementation of methionine enhanced the ergothioneine accumulation in the Ganoderma neo-japonicum mycelia – LEE W.Y., PARK E-J., and AHN J.K. – 2008 – Appl. Biochem. Biotechnol., 158(1):213-221
- In vitro reconstruction of mycobacterial ergothioneine biosynthesis – SEEBECK F.P. – 2010 – JACS, 132(19):6632-6633
- Ergothioneine accumulation in a medicinal plant Gastrodia elata – PARK E-J., LEE W.Y., KIM S.T., AHN J.K., and BAE E.K. – 2010 – J. Med. Plants Res., 4(12):1141-1147
- Dietary sources and antioxidant effects of ergothioneine – EY J., SCHÖMIG E., and TAUBERT D. – 2007 – J. Agric. Food Chem., 15(16):6466-6474
- Quantification of polyphenols and ergothioneine in cultivated mushrooms and correlation to total antioxidant capacity – DUBOST N.J., OU B., and BEELMAN R. – 2007 – Food Chem., 105(2):727-735
- Characteristics of antioxidant system in dog semen – STRZEZEK R., KOZIOROWSKA-GILUN M., KOWALOWKA M., and STRZEZEK J. – 2009 – Polish J. Vet. Sci., 12(1):55-60
- Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1 – KATO Y., KUBO Y., IWATA D., KATO S., SUDO T., SUGIURA T., KAGAYA T., WAKAYAMA T., HIRAYAMA A., SUGIMOTO M., SUGIHARA K., KANEKO S., SOGA T., ASANO M., TOMITA M., MATSUI T., WADA M., and TSUJI A. – 2010 – Pharm. Res., 27(5):832-840
- L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia – KUMOSANI T.A. – 2001 – Exp. Mol. Med., 33(1):20-22
- Discovery of the ergothioneine transporter – GRÜNDEMANN D., HARLFINGER S., GOLZ S., GEERTS A., LAZAR A., BERKELS R., JUNG N., RUBBERT A., and SCHÖMIG E. – 2005 – PNAS, 102(14):5256-5261
- Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations – GRIGAT S., HARLFINGER S., PAL S., STRIEBINGER R., GOLZ S., GEERTS A., LAZAR A., SCHÖMIG E., and GRÜNDEMANN D. – 2007 – Biochem. Pharmacol., 74(2):309-316
- Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation – KOBAYASHI D., AIZAWA S., MAEDA T., TSUBOI I., YABUUCHI H., NEZU J., TSUJI A., and TAMAI I. – 2004 – Exp. Hematol., 32(12):1156-1162
- An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis – TOKUHIRO S., YAMADA R., CHANG X., SUZUKI A., KOCHI Y., SAWADA T., SUZUKI M., NAGASAKI M., OHTSUKI M., ONO M., FURUKAWA H., NAGASHIMA M., YOSHINO S., MABUCHI A., SEKINE A., SAITO S., TAKAHASHI A., TSUNODA T., NAKAMURA Y., and YAMAMOTO K. – 2003 – Nat. Genet., 35(4):341-348
- Transport of organic cations across the blood-testis barrier – MAEDA T., GOTO A., KOBAYASHI D., and TAMAI I. – 2007 – Mol. Pharm., 4(4):600-607
- Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart – IWATA D., KATO Y., WAKAYAMA T., SAI Y., KUBO Y., ISEKI S., and TSUJI A. – 2008 – Drug Metab. Pharmacokinet., 23(3):207-215
- A comparison of the relative antioxidant potency of L-ergothioneine and idebenone – DONG K.K., DAMAGHI N., KIBITEL J., CANNING M.T., SMILES K.A., and YAROSH D.B. – 2007 – J. Cosmet. Dermatol., 6(3):183-188
- Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system – MARKOVA N.G., KARAMAN-JURUKOVSKA N., DONG K.K., DAMAGHI N., SMILES K.A., and YAROSH D.B. – 2009 – Free Radic. Biol. Med., 46(8):1168-1176
- Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations – TAMAI I., NAKANISHI T., KOBAYASHI D., CHINA K., KOSUGI Y., NEZU J-I., SAI Y., and TSUJI A. – 2004 – Mol. Pharm., 1(1):57-66
- Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway – HORVATH G., SCHMID N., FRAGOSO M.A., SCHMID A., CONNER G.E., SALATHE M., and WANNER A. – 2007 – Am. J. Respir. Cell Mol. Biol., 36(1):53-60
- Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium – GARRETT Q., XU S., SIMMONS P.A., VEHIGE J., FLANAGAN J.L., and WILLCOX M.D. – 2008 – Invest. Ophthalmol. Vis. Sci., 49(11):4844-4849
- Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver – SUGIURA T., KATO S., SHIMIZU T., WAKAYAMA T., NAKAMICHI N., KUBO Y., IWATA D., SUZUKI K., SOGA T., ASANO M., ISEKI S., TAMAI I., TSUJI A., and KATO Y.– 2010 – Drug Metab. Dispos., 38(10):1665-1672
- Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria – LAMHONWAH A.M., and TEIN I. – 2006 – Biochem. Biophys. Res. Commun., 345(4):1315-1325
- Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines – MAEDA T., HIRAYAMA M., KOBAYASHI D., MIYAZAWA K., and TAMAI I. – 2007 – Drug Metab. Dispos., 35(3):394-401
- Functional variants of OCTN cation transporter genes are associated with Crohn disease – PELTEKOVA V.D., WINTLE R.F., RUBIN L.A., AMOS C.I., HUANG Q., GU X., NEWMAN B., VAN OENE M., CESCON D., GREENBERG G., GRIFFITHS A.M., ST GEORGE-HYSLOP P.H., and SIMINOVITCH K.A. – 2004 – Nat. Gen., 36(5):471-475
- Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn’s disease – TÖRÖK H.-P., GLAS J., TONENCHI L., LOHSE P., MÜLLER-MYHSOK B., LIMBERSKY O., NEUGEBAUER C., SCHNITZLER F., SEIDERER J., TILLACK C., BRAND S., BRÜNNLER G., JAGIELLO P., EPPLEN J. T., GRIGA T., KLEIN W., SCHIEMONN U., FOLWACZNY M., OCHSENKÜHN T., and FOLWACZNY C. – 2005 – Gut, 54(10):1421-1427
- Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn’s disease – TAUBERT D., GRIMBERG G., JUNG N., RUBBERT A., and SCHÖMIG E. – 2005 – Gut, 54(10):1505-1506
- Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn’s disease – SILVERBERG M.S., DUERR R.H., BRANT S.R., BROMFIELD G., DATTA L.W., JANI N., KANE S.V., ROTTER J.I., PHILIP SCHUMM L., HILLARY STEINHART A., TAYLOR K.D., YANG H., CHO J.H., RIOUX J.D., and DALY M.J. – 2007 – Eur. J. Hum. Genet., 15(3):328-335
- Decreased proliferation and erythroid differentiation of K562 cells by siRNA-induced depression of OCTN1 (SLC22A4) Transporter Gene – NAKAMURA T., SUGIURA S., KOBAYASHI D., YOSHIDA K., YABUUCHI H., AIZAWA S., MAEDA T., and TAMAI I. – 2007 – Pharm. Res., 24(9):1628-1635
- Acute administration of Cefepime lowers L-carnitine concentrations in early lactation stage rat milk – LING B., and ALCORN J. – 2008 – J. Nutr., 138:1317-1322
- Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids – GILCHRIST S.E., and ALCORN J. – 2010 – Fundam. Clin. Pharmacol., 24(2):205-214
- An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox – FRANZONI F., COLOGNATO R., GALETTA F., LAURENZA I., BARSOTTI M., DI STEFANO R., BOCCHETTI R., REGOLI F., CARPI A., BALBARINI A., MIGLIORE L., and SANTORO G. – 2006 – Biomed. Pharmacother., 60(8):453-457
- Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex – ZHU B.Z., MAO L., FAN R.M., ZHU J.G., ZHANG Y.N., WANG J., KALYANARAMAN B. and FREI B. – 2010 – Chem. Res. Toxicol., 24(1):30-34
- Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine – COLOGNATO R., LAURENZA I., FONTANA I., COPPEDÉ F., SICILIANO G., COECKE S., ARUOMA O.I., BENZI L., and MIGLIORE L. – 2006 – Clin. Nutr., 25(1):135-145
- Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens – BOTTA C., Di GIORGIO C., SABATIER A.S., and De MÉO M. – 2008 – J. Photochem. Photobiol. B: Biology, 91(1):24-34
- Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death – JANG J.H., ARUOMA O.I., JEN L.S., CHUNG H.Y., and SURH YJ. – 2004 – Free Radic. Biol. Med., 36(3):288-299
- L-Ergothioneine scavenges superoxide and singlet oxygen and supresses TNF-α and MMP-1 expression in UV-irradiated human dermal fibroblasts – OBAYASHI K., KURIHARA K., OKANO Y., MASAKI H., and YAROSH D.B. – 2005 – J. Cosmet. Sci., 56(1):17-27
- Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo – SONG T.Y., CHEN C.L., LIAO J.W., OU H.C., and TSAI M.S. – 2010 – Food Chem. Toxicol., 48(12):3492-3499
- Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells – RAHMAN I., GILMOUR P.S., JIMENEZ L.A., BISWAS S.K., ANTONICELLI F., and ARUOMA O.I. – 2003 – Biochem. Biophys. Res. Commun., 302(4):860-864
- The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease – MARTIN K.R. – 2010 – J. Med. Food, 13(6):1340-1346
- Modulation of palmitic acid-induced cell death by ergothioneine: Evidence of an anti-inflammatory action – LAURENZA I., COLOGNATO R., MIGLIORE L., DEL PRATO S., and BENZI L. – 2008 – Biofactors, 33(4):237-247
- Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus) – ENCARNACION A.B., FAGUTAO F., HIRONO I., USHIO H., and OHSHIMA T. – 2010 – J. Agric. Food Chem., 58(4):2577-2585
- Antioxidative activity and antidiscoloration efficacy of ergothioneine in mushroom (Flammulina velutipes) extract added to beef and fish meats – BAO H.N., USHIO H., and OHSHIMA T. – 2008 – J. Agric. Food Chem., 56(21):10032-10040
- The effects of L-ergothioneine and L-ascorbic acid on the in vitro maturation (IVM) and embryonic development (IVC) of sheep oocytes – ÖZTÜRKLER Y., YILDIZ S., GÜNGÖR O., PANCARCI S.M., KACAR C., and ARI U.C. – 2010 – Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16(5):757-763
- Technologie de la conservation du sperme chez plusieurs vertébrés domestiques: protection des lipides membranaires, intégrité du noyau et élargissement des méthodes – LABBE C., BLESBOIS E., LEBOEUF B., MARTORIATI A., GUILLOUET P., STRADAIOLI G., and MAGISTRINI M. – 2003 – Les actes du BRG, 4:143-157
- Effects of ergothioneine on diabetic embryopathy in pregnant rats – GUIJARRO M.V., INDART A., ARUOMA O.I., VIANA M., and BONET B. – 2002 – Food Chem. Toxicol., 40(12):1751-1755
- Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70 – BEDIRLI A., SAKRAK O., MUHTAROGLU S., SOYUER I., GULER I., RIZA ERDOGAN A., and SOZUER E.M. – 2004 – J. Surg. Res., 122(1):96-102
- Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury – SAKRAK O., KEREM M., BEDIRLI A., PASAOGLU H., AKYUREK N., OFLUOGLU E., and GÜLTEKIN F.A. – 2007 – J. Surg. Res., 144(1):36-42
- L-Ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids – DEIANA M., ROSA A., CASU V., PIGA R., ASSUNTA DESSÌ M., and ARUOMA O.I. – 2004 – Clin. Nutr., 23(2):183-193
- Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model – MONCASTER J.A., WALSH D.T., GENTLEMAN S.M., JEN L.S. and ARUOMA O.I. – 2002 – Neurosci. Lett., 328(1):55-59
- Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study – TAUBERT D., LAZAR A., GRIMBERG G., JUNG T., RUBBERT A., DELANK K.S., PERNIOK A., and SCHÖMIG E. – 2006 – J. Rheumatol., 33(11):2139-2145
- Imidazole-based erythrocyte markers of oxidative stress in preeclampsia: An NMR investigation – TURNER E., BREWSTER J.A., SIMPSON N.A., WALKER J.J., and FISHER J. – 2009 – Reprod. Sci., 16(11):1040-1051
- Increased ergothioneine tissue concentrations in carriers of the Crohn’s disease risk-associated 503F variant of the organic cation transporter OCTN1 – TAUBERT D., JUNG N., GOESER T., and SCHÖMIG E. – 2009 – Gut., 58(2):312-314
- Evaluation of the safety of the dietary antioxidant ergothioneine using the bacterial reverse mutation assay – SCHAUSS A.G., VERTESI A., ENDRES J.R., HIRKA G., CLEWELL A., QURESHI I., and PASICS I. – 2010 – Toxicology, 278(1):39-45
- Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage – AMES B.N. – 2006 – PNAS, 103(47):17589-17594
- Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake – AMES B.N. – 2010 – J. Nucleic Acids, 2010:Article ID 725071
From 2011-
- The Neurospora crassa mutant NcΔEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination – BELLO M.H., BARRERA-PEREZ V., MORIN D., and EPSTEIN L. – 2012 – Fung. Gen. Biol., 49(2):160-172
- Quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry – WANG L-Z., THUYA W-L., TOH D.S-L., LIE M.G-L., LAU J-Y.A., KONG L-R., WAN S-C., CHUA K-N., LEE E.J-D., and GOH B-C. – 2012 – J. Mass Spectrom., 48:406-412
- Organic cation transporters in human nasal primary culture: expression and functional activity – SHAO D., MASSOUD E., ANAND U., PARIKH A., COWLEY E., CLARKE D., and AGU R.U. – 2013 – Ther. Deliv., 4(4):439-451
- The ergothioneine transporter controls and indicates ergothioneine activity–a review – GRÜNDEMANN D. – 2012 – Prev. Med., 54(Suppl.):S71-S74
- Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels – PFEIFFER C., BACH M., BAUER T., CAMPOS da PONTE J., SCHÖMIG E., and GRÜNDEMANN D. – 2015 – Free Radic. Biol. Med., http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.026
- Association of SLC22A4 gene polymorphism with rheumatoid arthritis in the Chinese population – REN T-L., HAN Z-J., YANG C-J., HANG Y-X., FANG D-Y., WANG K., ZHU X., JI X-J., and ZHOU F-F. – 2014 – J. Biochem. Mol. Toxicol., doi: 10.1002/jbt.21554
- Crohn’s disease and genetic hitchhiking at IBD5 – HUFF C.D., WITHERSPOON D.J., ZHANG Y., GATENBEE C., DENSON L.A., KUGATHASAN S., HAKONARSON H., WHITING A., DAVIS C.T., WU W., XING J., WATKINS W.S., BAMSHAD M.J., BRADFIELD J.P., BULAYEVA K., SIMONSON T.S., JORDE L.B., and GUTHERY S.L. – 2012 – Mol. Biol. Evol., 29(1):101-111
- A density functional theory investigation into the binding of the antioxidants ergothioneine and ovothiol to copper – De LUNA P., BUSHNELL E.A.C., and GAULD J.W. – 2013 – J. Phys. Chem. A, 117(19):4057-4065
- Ergothioneine as an anti-oxidative/anti-inflammatory component in several edible mushrooms – ITO T., KATO M., TSUCHIDA H., HARADA E., NIWA T., and OSAWA T. – 2011 – Food Sci. Technol. Res., 17(2):103-110
- Endogenous ergothioneine is required for wild type levels of conidiogenesis and conidial survival but does not protect against 254 nm UV-induced mutagenesis or kill – BELLO M.H., MOGANNAM J.C., MORIN D., and EPSTEIN L. – 2014 – Fungal Genet. Biol., 73:120-127
- Ergothioneine protects Streptomyces coelicolor A3(2) from oxidative stresses – NAKAJIMA S., SATOH Y., YANASHIMA K., MATSUI T., and DAIRI T. – 2015 – J. Biosci. Bioeng., doi: 10.1016/j.jbiosc.2015.01.013
- Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A – ZHAO Q., WANG M., XU D., ZHANG Q., and LIU W. – 2015 – Nature, 518(7537):115-119
- The effect of ergothioneine on clastogenic potential and mutagenic activity: genotoxicity evaluation – SCHAUSS A.G., BERES E., VERTESI A., FRANK Z., PASICS I., ENDRES J., ARUOMA O.A., and HIRKA G. – 2011 – Int. J. Toxicol., 30(4):405-409
- Reproductive safety evaluation of L-ergothioneine – FORSTER R., SPEZIA F., PAPINEAU D., SABADIE C., ERDELMEIER I., MOUTET M., and YADAN JC. – 2015 – Food Chem. Toxicol., 80:85-91
- The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation – WEIGAND-HELLER A.J., KRIS-ETHERTON P.M., and BEELMAN R.B. – 2012 – Prev. Med., 54(Suppl.):S75-S78
- Effect of Shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise – ZEMBRON-LACNY, A., GAJEWSKI, M., NACZK, M., and SIATKOWSKI, I. – 2013 – J. Physiol. Pharmacol., 64(2):249-254
- Cysteine as a sustainable sulfur reagent for the protecting-group-free synthesis of sulfur-containing amino acids: biomimetic synthesis of L-ergothioneine in water – ERDELMEIER I., DAUNAY S., LEBEL R., FARESCOUR L. and YADAN J.C. – 2012 – Green Chem., 14(8):2256-2265
Reviews
The unusual amino acid L-ergothioneine is a physiologic cytoprotectant – PAUL B.D., and SNYDER S.H. – 2010 – Cell Death Differ., 17(7):1134-1140
Ergothioneine; antioxidant potential, physiological function and role in disease – CHEAH I.K., and HALLIWELL B. – 2012 – Biochim. Biophys. Acta, 1822(5):784-793
Ergothioneine Antioxidant Function: From Chemistry to Cardiovascular Therapeutic Potential – SERVILLO L., D’ONOFRIO N., and BALESTRIERI ML. – 2017 – J; Cardiovasc. Pharmacy., 69(4):183-191
Ergothioneine: a diet-derived antioxidant with therapeutic potential – HALLIWELL B., CHEAH IK., TANG RMY. – 2018 – FEBS Letter, 592(20):3357-3366
Clinical Trials
The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation – WEIGAND-HELLER A.J., KRIS-ETHERTON P.M., and BEELMAN R.B. – 2012 – Prev. Med., 54(Suppl.):S75-78
Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement – BENSON K.F., AGER D.M., LANDES B., ARUOMA O.I., and JENSEN G.S. – 2012 – Prev. Med., 54(Suppl.):S83-S89
Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults – SOTGIA S., ZINELLU A., MANGONI A.A., PINTUS G., ATTIA J., CARRU C., and McEVOY M. – 2014 – PLoS ONE, 9(1):e84918
A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms) – CALVO MS., MEHROTRA A., BEELMAN RB., NADKARNI G.,
WANG L., CAI W., GOH BOON C., KALARAS MD., URIBARRI J. – 2016 – Plant Foods Hum. Nutr., 71(3):245-251
The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore -FENGA L., CHEAH IKM., NG MMX., , LIC J., CHAN SM., LIM MAHENDRAN SL., KUA EH., and HALLIWELL B. – 2019 – J. Alzheimer’s Disease, 68(1):197-203
Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease – SMITH E., OTTOSSON F., HELLSTRAND S., ERICSON U., ORHO-MELANDER M., FERNANDEZ C., MELLANDER O. – 2019 – Heart, 0:1-7
Nutrition
Beverages:
2018_Sotgia_2018_Hercynine in beverages.pdf
Milk:
Ultra-performance liquid chromatographic determination of L-ergothioneine in commercially available classes of cow milk – SOTGIA S., PISANU E., CAMBEDDA D., PINTUS G., CARRU C., and ZINELLU A. – 2014 – J. Food Sci., 79(9):C1683-1687
Dairy:
2015_Yagdiran_2015_OCTN1&Lactation.pdf
2018_Pan_2018_Et&Dairy tradit. vs comm. .pdf
2019_Garcia-Lino_2019_OCTN1&Milk.pdf
2019_Matazel_2019_EGT in milk&Diet exposure.pdf
Micronutrients
2015_Bailey_2015_Micronutrient deficiencies.pdf
2018_Höller_2018_Micronutrients analyses.pdf
Protection Aliments:
2014_Cai_2014_Et&fish quality.pdf
2017_Dehghani_2017_Et&Sea food preservation.pdf
2017_Pahila_2017_Et&Salmon.pdf
2019_Thangavelu_2019_EGT&preservation of food.pdf
Brain
Ergothioneine protects against neuronal injury induced by β-amyloid peptide in mice – YANG N-C., LIN H-C., WU J-H., OU H-C., CHAI Y-C., TSENG C-Y., LIAO J-W., and SONG T-Y. – 2012 – Food Chem. Toxicol., 50(11):3902-3911
Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation – NAKAMICHI N., TAGUCHI T., HOSOTANI H., WAKAYAMA T., SHIMIZU T., SUGIURA T., ISEKI S., and KATO Y. – 2012 – Neurochem. Int., 61(7):1121-1132
Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons – ISHIMOTO T., NAKAMICHI N., HOSOTANI H., MASUO Y., SUGIURA T., and KATO Y. – 2014 – PLoS ONE, 9(2):e89434
Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose – SONG TY., LIN HC., CHEN CL., WU JH., LIAO JW., and HU ML. – 2014 – Free Radic. Res., 48(9):1049-1060
Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice – SHIMIZU T., MASUO Y., TAKAHASHI S., and KATO Y. – 2015 – Drug Metab. Pharmacokinet., doi:10.1016/j.dmpk.2015.02.003
Identification of novel biomarkers for Parkinson’s disease by metabolomic technologies – HATANO T., SAIKI S., OKUZUMI A., MOHNEY R.P., and HATTORI N. – 2015 – J. Neurol. Neurosurg. Psychiatry, doi: 10.1136/jnnp-2014-309676
2016_Ishimoto_2016_Et&neuronal Stem Cells_MTU09-14.pdf
2017_Song_2017_ET&brain protection.pdf
2017_Ishimoto_2017_Et&mTORC1 activation&NeuralStemCells.pdf
2018_Ishimoto_2018_OCTN1@Microglial Cells modulation.pdf
2014_Song_2014_Et&Melatonin.pdf
2016_Nakamichi_2016_Et&antidepressant effect.pdf
Cardiovascular
Uptake and protective effects of ergothioneine in human endothelial cells – LI R.W.S., YANG C., SIT A.S.M., KWAN Y.W., LEE S.M.Y., HOI M.P.M., CHAN S.W., HAUSMAN M., VANHOUTTE P.M., and LEUNG G.P.H. – 2014 – J. Pharmacol. Exp. Ther., 350(3):691-700
Ergothioneine represses inflammation and dysfunction in human endothelial cells exposed to oxidized low-density lipoprotein – SAING L., WEI YC., and TSENG CJ. – 2015 – Clin. Exp. Pharmacol? Physiol., doi: 10.1111/1440-1681.12374
2017_Servillo_2107_Et&Endo cells.pdf
2018_Gökce_2018_EGT&EC protection against HgCl2.pdf
2019_D’Onofrio_2019_EGT&SIRT1&MicroR33@thrombus burden in STEMI patients.pdf
2019_Smith_2019_EGT as biomarker in Prospective clinical study .pdf
Metabolic
2016_D’Onofrio_2016_Et&Sirt1&6.pdf
2017_Pretorius_2017_Et&amyloidogenesis.pdf
Immune System
2017_Yoshida_2017_Et&Immunomodulation.pdf
2006_Xiao_2006_EGT&Virus Inhibition .pdf
2019_Gallego_2019_Mushrooms extracts@inhibition of HCV.pdf
Kidneys
2017_Shinozaki_2017_Et&CDK.pdf
Liver
2015_Cheah_2015_Et as Protection molecule.pdf
2016_Tang_2016_Et&liver Fibrosis.pdf
2019_Milito_2019_EGT&OvoSH&liver Fibrosis_review.pdf
Lung
Effect of Ergothioneine on acute lung injury and inflammation in cytokine insufflated rats – REPINE J.E., and ELKINSN.D. – 2012 – Prev. Med., 54(Suppl.):S79-S82
2015_Nickel_2015_Et&COPD_poster.pdf
2016_Erhardt_2016_Et&tobacco induced stress_poster.pdf
2016_Nickel_2016_Et&lung protection_mini symposium.pdf
2016_Tang_2016_Et&Pumonary Fibrosis.pdf
2016_Zinellu_2016_Et&Asthma&COPD.pdf
2017_Nickel_2017_Et&tobacco damage_poster.pdf
2017_Selo_2017_Et&Nrf2 in Lung.pdf
2019_Stirling_2019_EGT&Protection against Lung irradiation.pdf
Muscle
2013_Zambron-Lacny_2013_Et&Exercice.pdf
Pre-eclampsia
2018_Kerley_2018_EGT&Pre-eclampsia.pdf
2018_Williamson_2018_EGT&Pre-eclampsia.pdf
Reproduction
Antioxidant defence system of boar cauda epididymidal spermatozoa and reproductive tract fluids – KOZIOROWSKA-GILUN M., KOZIOROWSKI M., FRASER L., and STRZEZEK J. – 2011 – Reprod. Dom. Anim., 46(3):527-533
Paramount levels of ergothioneine transporter SLC22A4 MRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma – NIKODEMUS D., LAZIC D., BACH M., BAUER T., PFEIFFER C., WILTZER L., LAIN E., SCHÖMIG E., and GRÜNDEMANN D. – 2011 – J. Physiol. Pharmacol., 62(4):411-419
Effects of cysteine and ergothioneine on post-thawed Merino ram sperm and biochemical parameters – ÇOYAN K., BASPINAR N., BUCAK M.N., and AKALIN P.P. – 2011 – Cryobiology, 63(1):1-6
Ergothioneine attenuates the DNA damage of post-thawed Merino ram sperm – ÇOYAN K., BUCAK M.N., BASPINAR N., TASPINAR M., and AYDOS S. – 2012 – Small Rumin. Res.,106(2-3):165-167
Effect of L-(+)-ergothioneine (EGT) on freezability of ram semen – ARI U.C., KULAKSIZ R., OZTURKLER Y., YILDIZ S., and LEHIMCIOGLU N.C. – 2012 – Int. J. Anim. Vet. Adv., 4(6):378-383
L-ergothioneine supplementation during culture improves quality of bovine in vitro–produced embryos – ZULLO G., ALBERO G., NEGLIA G., DE CANDITIIS C., BIFULCO G., CAMPANILE G., and GASPARRINI B. – 2015 – Theriogenology, doi:10.1016/j.theriogenology.2015.10.008
2015_Sotgia_2015_EGT in follicular fluids.pdf
2019_Dare_2019_L-Ergothioneine_Supplement_Protect_Testicular_Func.pdf
Skin
2012_Liao_ergothioneine&tyrosinase.pdf
2012_Popescu_ergothioneine&photoprotection.pdf
L-Ergothioneine protects skin cells against UV-induced damage – A preliminary study – BAZELA K., SOLYGA-ZUREK A., DEBOWSKA R., ROGIEWICZ K., BARTNIK E., and ERIS I. – 2014 – Cosmetics, 1:51-60
Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes – EMANUELE E., BERTONA M., SANCHIS-GOMAR F., PAREJA-GALEANO H., and LUCIA A. – 2014 – Biomed. Rep., 2(5):755-759
Dermato-protective Properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant Genes in UVA-irradiated Human keratinocytes – HSEU YC., LO HW., KORIVI M., TSAI YC., TANG MJ., and YANG HL. – 2015 – Free Radic. Biol. Med., 86:102-117
2015_Pfeiffer_2015_ergothioneine&zebrafish&skin.pdf
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