Nutrition – Probiosel®

Selenium-enriched Probiotics as a new source of selenium

« A probiotic is a living microorganism that, when consumed in adequate amounts, produces a benefit to the health of the host « (FAO / WHO, 2001).
The main microorganisms classified as probiotics are lactobacilli, bifidobacteria, Escherichia coli and yeast Sacchromyces boulardii. Probiotics are incorporated into foods – these are called functional foods or health foods.

« A health food or nutraceutical is a food or food ingredient, consumed to provide the necessary agents for the structure and functions of the body and deemed to have a beneficial effect on health, whether preventive or curative.  »

Research suggests that Bifidobacteria have several potential probiotic properties, particularly antimicrobial, immunomodulatory (i.e, balancing of natural resistance to infections and diseases), as well as cancer. They also exert an influence on the balance of the intestinal microflora facilitating in particular the digestion; they improve lactose tolerance and digestibility of dairy products; they promote the synthesis of B vitamins and improve the absorption of calcium.

« These products are the embodiment of the concept of health through food and are therefore part of the prevention of diseases. »

Probiotics are considered the essential health concept of the 21st century. According to Prof. Luc Montagnier (co-discoverer of the AIDS virus) « The medical field must move from a curative approach to a preventive – even integrative approach. » This is the message he delivered at the Montreal Conference, as part of the International Economic Forum of the Americas. ( The stakes are therefore major and the interests considerable.

ProBiosel® a unique technology for Probiotics enrichment in L- selenomethionine

Name : ProBiosel® – unique and patented selenomethionine- enriched Lactobaccilus technology

Assay : 2,000 – 4,000 ppm Equivalent Selenium

Physical Form : lyophilised off-white powder

Method of Manufacture : Fermentation

Manufacturing Standard : to define given the domestic regulatories

Quality Control : Inductively Coupled Plasma / Mass Spectrometry method (ICP/MS method)

Security : Batch Release Certificate

Accepted Indications in Europe:

  1. Contributes to the protection of cell constituents from For Selenium oxidative damage (1)
  2. Contributes to the normal function of the immune system (1)
  3. Contributes to normal thyroid function (1)
  4. Contributes to normal spermatogenesis function (1)
  5. Contributes to the maintenance of normal hair (2)
  6. Contributes to the maintenance of normal nails (2)

Dosing in Human : 40 – 80μg Equivalent Se/day/person corresponding to 20 – 40 mg ProBiosel®/day/person

Toxicity : Regulatory Dossier for NutraSelen® used in the ProBiosel® technology is available

Side Effects : In case of selenium overdosage exclusively (NOAEL : 850 μg Equivalent Se/day/person)

Market Authorization : to get. However it has to be noted that selenomethionine is already authorized in Europe. If the lactobaccilus strain of interest is authorized then the Se-enriched lactobaccilus should be authorised aready to market.

Intellectual Property : unique technology owns by Tetrahedron’proprietary patent (FR2935393 / US8535931 / WO2010023291).

Competition Benefits : new and cheap organic source of selenomethionine with

  • better bioavailability (x8-10) / Sodium Selenide (mineral selenium)
  • better bioavailability (x2-2.5) / selenized yeasts
  • better enrichment efficacy ( x 1 .25-1.50) / Sodium Selenide
  • better control of quality / selenized yeasts
  • better safety ( x 20-40) / Sodium Selenide

Applications : Food ingredient
Food Supplement


  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to selenium and protection of DNA, proteins and lipids from oxidative damage (ID 277, 283, 286, 1289, 1290, 1291, 1293, 1751) , function of the immune system (ID 278), thyroid function (ID 279, 282, 286, 1289, 1290, 1291, 1293), function of the heart and blood vessels (ID 280), prostate function (ID 284), cognitive function (ID 285) and spermatogenesis (ID 396) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission– 2009 – EFSA Journal, 7(9):1220 [24 pp.]
  2. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to selenium and maintenance of normal hair (ID 281), maintenance of normal nails (ID 281), protection against heavy metals (ID 383), maintenance of normal joints (ID 409), maintenance of normal thyroid function (ID 410, 1292), protection of DNA, proteins and lipids from oxidative damage (ID 410, 1292), and maintenance of the normal function of the immune system (ID 1750) pursuant to Article 13(1) of Regulation (EC) No 1924/2006– 2010 – EFSA Journal, 8(10):1727 [18 pp.]