L-ergothioneine as a protective agent for Skin Care

To cope with oxidative stress, skin is endowed with antioxidant defenses which prevent from ROS- and RNS-mediated alterations or damage. However, antioxidant defenses have been shown to be depleted following UVA irradiation.
The activation of the « master » transcription factor Nrf2 appears to play an important role in providing antioxidant protection against UVA.
Numerous scientific publications have demonstrated the protective effects of L-ergothioneine (EGT in the following scheme) against UV-induced skin injuries. A recent and important paper demonstrates the “Dermato-protective properties of ergothioneine through induction of antioxidant genes in UVA-irradiated human keratinocytes” (Hseu, 2016 – Free Rad. Biol. Med., 86 :102-117).

UVA-induced ROS, mitochondrial dysfunction, DNA damage was reversed by EGT pretreatment via Nrf2/ARE-mediated antioxidant status in human keratinocytes. (from Hseu et al.; 2016)

In this context, the use of our product Bioneine® as pure L-ergothioneine has potential benefits and may complement the effect of UV filters.